Material Drying
4 조회수
COC Packaging Insufficient Barrier Property
문제 현상
During the shelf life of COC pharmaceutical packaging, moisture or oxygen transmission exceeds the standard, the stability of the contents is affected, and the barrier test data is critical.
원인 분석
COC has excellent water vapor barrier but average oxygen barrier; a single COC structure cannot meet high barrier requirements; thickness fluctuations and sealing defects further weaken the barrier performance.
해결 방법
①For high barrier requirements, use a multilayer composite structure of COC and barrier resin; ②increase wall thickness or coating to improve the barrier; ③seal integrity testing; ④shelf-life stability test verification.
핵심 요약
COC barrier property should be distinguished in the two dimensions of water vapor and oxygen; multilayer structure is the standard solution for high barrier; shelf-life data is the final criterion.; After confirming effectiveness, fix the parameters and practices into the work instruction to prevent recurrence
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