Thermoforming
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Narrow processing window of PEOX in pharmaceutical capsule applications
Problem Phenomenon
When PEOX pharmaceutical capsules (replacing gelatin) are injection molded or thermoformed, mold filling is incomplete, capsule wall thickness is uneven, product strength is low, and capsule rupture rate is high.
Cause Analysis
PEOX has a narrow melting range (65-75°C) and the processing window is only about 10°C; improper mold temperature control with temperature distribution >3°C causes flow differences in various parts; PEOX melt adheres strongly to metal walls making demolding difficult; improper molecular weight selection (too high leads to poor fluidity, too low leads to insufficient strength).
Solution
Select PEOX with suitable molecular weight (Mv 200,000-500,000) to balance fluidity and strength; precision mold temperature control ±1°C with zone heating/cooling; mold surface treatment (PTFE or DLC coating) to reduce adhesion and add mold release agent; optimize '2079851475616104452 parameters with low injection speed and high holding pressure time.
Key Takeaway
PEOX pharmaceutical capsule processing is precision engineering, and mold temperature control and surface coating are the basis for ensuring product quality.
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