Material Analysis
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Molecular weight selection and processing matching of PEOX in pharmaceutical sustained-release film
Problem Phenomenon
When PEOX pharmaceutical sustained-release film is extruded and cast, due to improper molecular weight selection, the processing temperature window cannot simultaneously meet the requirements of fluidity, film strength and dissolution rate.
Cause Analysis
If the molecular weight is too high, the fluidity is insufficient and it is difficult to cast into a film; if the molecular weight is too low, the film strength is insufficient and the dissolution rate is too fast to meet the sustained-release design requirements.
Solution
Select medium molecular weight PEOX (Mv about 500,000) + low molecular weight PEOX (Mv about 100,000) blended at a ratio of 4:1 to achieve a balance of processability and product performance.
Key Takeaway
PEOX pharmaceutical film needs to balance processability and product performance by blending different molecular weights.
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