Material Drying
5 views
PCL slow biodegradation rate
Problem Phenomenon
The degradation cycle of PCL products is 3~4 years, which is too long and does not meet rapid degradation applications.
Cause Analysis
The semi-crystalline structure of PCL degrades slowly; high crystallinity slows hydrolysis; high molecular weight; environmental conditions; blending modification needs.；During on-site troubleshooting, verify item by item according to this mechanism, and avoid blindly adjusting the machine based solely on experience
Solution
①Blending with fast-degrading polymers; ②Crystallinity regulation; ③Molecular weight selection; ④Environmental condition optimization; ⑤Degradation test verification.；After adjustment, take continuous samples to verify the effect, and resume mass production only after confirming stability
Key Takeaway
PCL slow degradation is an advantage for long-term implantation but also an obstacle for rapid applications; blending is a regulation means; tests verify the rate.；After confirming effectiveness, solidify the parameters and practices into the work instruction to prevent recurrence
Was this helpful?
0 people found this helpful
Thank you for your feedback!