Material Drying
2 views
Control of dissolution rate abnormality in PEOX hot pressing pharmaceutical films
Problem Phenomenon
During PEOX hot pressing production of pharmaceutical films, the problem of uneven dissolution rate occurs.
Cause Analysis
Mainly due to the processing temperature deviating from the window +70-90°C, moisture content >0.5% exceeding the standard, and shear heat accumulation.
Solution
Strictly control the temperature within the recommended range, fully dry the material to moisture content <0.1%, and shorten the residence time.
Key Takeaway
PEOX processing requires precise control of the three elements of temperature, humidity, and residence time.
Was this helpful?
0 people found this helpful
Thank you for your feedback!